ESTIMATION OF ANTIHAEMOPHILIC GLOBULIN (AHG) CONCENTRATION FOR ASSESSMENT OF RISK FACTORS AMONG MODERATE-INTENSITY EXERCISE PERFORMERS
DOI:
https://doi.org/10.63075/emrvx750Keywords:
Antihaemophilic Globulin, Exercise, Coagulation, Risk Assessment, Factor Viii, Sports HematologyAbstract
Background and Study Aim: Antihaemophilic globulin (AHG, also known as factor VIII) plays a crucial role in the coagulation cascade, and its plasma concentration may be influenced by exercise. The present study sought to provide estimates of AHG concentrations and (admittedly indirect) evidence on the productive pathways of AHG among subjects participating in moderate-level physical activity, with implications for personalized exercise prescription as well as risk management in physically active cohorts.
Material and Methods: A randomized controlled experimental design was utilized. Twenty healthy male university athletes (aged 18–25) were randomly assigned to either an exercise intervention group (n = 10; eight-week moderate-intensity aerobic protocol) or a control group (n = 10; no exercise intervention). The primary outcome was plasma AHG concentration; secondary outcomes included prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen levels, which were measured both before and after the intervention. All procedures were ethically approved, and informed consent was obtained before participation. Data were analyzed using repeated-measures ANOVA and independent t-tests.
Results: Post-intervention, the exercise group demonstrated a significant increase in AHG concentration (mean ± SD: pre 0.96 ± 0.13 IU/mL, post 1.22 ± 0.15 IU/mL, p < .001). PT and TT were prolonged, while fibrinogen levels showed a marked decrease. No significant changes were observed in the control group. Effect sizes were moderate to large for key coagulation parameters.
Conclusion: Low-moderate exercise provokes a dramatic rise in AHG and modifies hemostasis kinetics, which may be favourable adaptations for the homeostatic equilibrium. Nevertheless, one should consider players’ individual risk factor evaluation for the precise exercise practice of athletes.
