SYNTHESIS, CHARACTERIZATION, AND BIOACTIVITY OF PARA AMINO BENZOIC ACID (PABA) AZO DERIVATIVE

Abstract

Azo compounds are characterized by the presence of azo group (-N=N-). In this study, the compound named (E)-4-((8-hydroxiquinolin-5-yl) diazinyl) benzoic acid was synthesized through a diazo-coupling reaction between Para-aminobenzoic acid and 8-hydroxyquinoline with yield of 85%. The melting point of the compound was found to be greater than 350℃. The prepared compound was purified through a single solvent and two solvent recrystallization methods. The structure of the novel synthesized compound was confirmed through UV-visible, infra-red, and NMR Spectroscopies. The prepared compound was tested for its antifungal activity against Aspergillus terreus using the disc diffusion method. Significant antifungal activity was exposed by the novel synthesized compound against the mentioned fungus strain.